GENERAL HISTOLOGY

Detailed explanation-1: -The neuromuscular junction (NMJ) is a synaptic connection between the terminal end of a motor nerve and a muscle (skeletal/ smooth/ cardiac). It is the site for the transmission of action potential from nerve to the muscle. It is also a site for many diseases and a site of action for many pharmacological drugs.

Detailed explanation-2: -The neuromuscular junction is essentially comprised of two different types of cells: skeletal muscle cells and a type of nerve cell called motor neurons.

Detailed explanation-3: -In vertebrates, motor neurons release acetylcholine (ACh), a small molecule neurotransmitter, which diffuses across the synaptic cleft and binds to nicotinic acetylcholine receptors (nAChRs) on the cell membrane of the muscle fiber, also known as the sarcolemma.

Detailed explanation-4: -The gap between the motor neuron and the muscle fiber is the neuromuscular junction where different types of proteins change their shape according to the signals received and helps the muscle fiber either to contract or relax.