GENERAL HISTOLOGY

MUSCLE

SKELETAL MUSCLE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
The mechanical force of contraction is generated by:
A
shortening of the thick filaments
B
the “accordian-like” folding of think and thick filaments
C
a sliding of thin filaments past thick ones
D
the temporary disappearance of thin filaments
Explanation: 

Detailed explanation-1: -The widely accepted theory describing muscular contraction is called the sliding filament theory, which proposes that the active force is generated as actin filaments slide past the myosin filaments, resulting in contraction of an individual sarcomere.

Detailed explanation-2: -During contraction, the myosin heads extend from the thick filament surface and attach to actin in the thin filaments, causing the filaments to slide past each other in a cyclic, ATP-driven process.

Detailed explanation-3: -Summary. According to the sliding filament theory, a muscle fiber contracts when myosin filaments pull actin filaments closer together and thus shorten sarcomeres within a fiber. When all the sarcomeres in a muscle fiber shorten, the fiber contracts.

Detailed explanation-4: -Muscle contraction thus results from an interaction between the actin and myosin filaments that generates their movement relative to one another. The molecular basis for this interaction is the binding of myosin to actin filaments, allowing myosin to function as a motor that drives filament sliding.

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