GENERAL HISTOLOGY

MUSCLE

SKELETAL MUSCLE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Which thin filament protein bind to Ca during muscle contraction?
A
Actin
B
Myosin
C
Troponin
D
Tropomyosin
Explanation: 

Detailed explanation-1: -Troponin plays a central role in the calcium-regulation of muscle contraction: Troponin is the sole calcium-binding component of thin filaments (actin-tropomyosin-troponin complex) of striated muscles.

Detailed explanation-2: -Each heartbeat is triggered by a pulse of intracellular calcium ions which bind to troponin on the actin-containing thin filaments of heart muscle cells, initiating a change in filament structure that allows myosin to bind and generate force.

Detailed explanation-3: -When calcium binds to troponin, the troponin changes shape, removing tropomyosin from the binding sites. The sarcoplasmic reticulum stores calcium ions, which it releases when a muscle cell is stimulated; the calcium ions then enable the cross-bridge muscle contraction cycle.

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