GENERAL HISTOLOGY

MUSCLE

SMOOTH MUSCLE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Ca2+ involved in contraction?
A
Cardiac
B
Smooth
C
Skeletal
D
None of the above
Explanation: 

Detailed explanation-1: -Ca2+ ions that are stored in the SR are released to the cytosol via the activated RyR1, where they bind to troponin C, which then activates a series of contractile proteins and induces skeletal muscle contraction.

Detailed explanation-2: -Skeletal muscle contraction is initiated by an increase in cytoplasmic Ca2+ concentration ([Ca2+]). This Ca2+ binds to troponin C, which permits actin-myosin interaction.

Detailed explanation-3: -Calcium triggers contraction by reaction with regulatory proteins that in the absence of calcium prevent interaction of actin and myosin. Two different regulatory systems are found in different muscles.

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