GENERAL HISTOLOGY

Detailed explanation-1: -Gap junctions play a central role integrating the smooth muscle cell function by coordinating changes in both membrane potential and intracellular Ca2+ between adjacent smooth muscle cells (22–24).

Detailed explanation-2: -Smooth muscle is made up of cells that contain a single central nucleus. The cells stick together and are connected by specialised cell junctions, called gap junctions. The cells are spindle shaped, and the nucleus is central.

Detailed explanation-3: -Gap junctions are aggregates of intercellular channels that permit direct cell–cell transfer of ions and small molecules. Initially described as low-resistance ion pathways joining excitable cells (nerve and muscle), gap junctions are found joining virtually all cells in solid tissues.

Detailed explanation-4: -Multiunit smooth muscle cells do not possess gap junctions, and contraction does not spread from one cell to the next.