GENERAL HISTOLOGY

NERVOUS SYSTEM SPECIAL SENSE

CEREBELLUM

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
A friend has taken a job in a neuroscience research lab, and is studying neurons in a freshwater snail. He has been told to calculate the equilibrium potential of K+. Which equation will he use and what other information will he need?
A
Nernst equation; concentration of K+ inside and outside of the cell
B
Nernst equation; concentration of K+ inside and outside of the cell and permeability of K+
C
Goldman equation; concentration of K+ inside and outside of the cell
D
Goldman equation; concentration of K+ inside and outside of the cell and permeability of K+
E
Nernst equation; concentration of K+, Na+, and Cl-inside and outside of the cell
Explanation: 

Detailed explanation-1: -Moreover, K+ is a positively charged ion that has an intracellular concentration of 120 mM, an extracellular concentration of 4 mM, and an equilibrium potential of-90 mV; this means that K+ will be in electrochemical equilibrium when the cell is 90 mV lower than the extracellular environment.

Detailed explanation-2: -Equilibrium (or reversal) potentials In mammalian neurons, the equilibrium potential for Na+ is  +60 mV and for K+ is  -88 mV. for a given ion, the reversal potential can be calculated by the Nernst equation where: R = gas constant. T = temperature (in oK)

Detailed explanation-3: -A strong local potential moves the membrane potential to-55mV. 4. Sodium ion channels open causing membrane potential to become more positive.

Detailed explanation-4: -For this course you should MEMORIZE THREE STANDARD NERNST POTENTIALS: Nernst potential for Na+ = +55mV, Nernst potential for Cl-=-65mV, Nernst potential for K+ =-90mV. (The Nernst potential is the voltage which would balance out the unequal concentration across the membrane for that ion.

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