GENERAL HISTOLOGY

Detailed explanation-1: -The basal ganglia are particularly associated with movement disorders. Associated with damage to the BG are: tremors; involuntary muscle movements; abnormal increase in tone; difficulty initiating movements; abnormal posture.

Detailed explanation-2: -Pathophysiologically, tremor is linked to altered activity in not one, but two distinct circuits: the basal ganglia, which are primarily affected by dopamine depletion in Parkinson’s disease, and the cerebello-thalamo-cortical circuit, which is also involved in many other tremors.

Detailed explanation-3: -Damage to the basal ganglia cells may cause problems controlling speech, movement, and posture. This combination of symptoms is called parkinsonism. A person with basal ganglia dysfunction may have trouble starting, stopping, or sustaining movement.

Detailed explanation-4: -Parkinson’s disease. This slowly progressive disease causes tremor, muscle stiffness, slow or decreased movement, or imbalance. It may also cause other symptoms not related to movement such as reduced sense of smell, constipation, acting out dreams and a decline in cognition.