GENERAL HISTOLOGY

Detailed explanation-1: -Gage didn’t die. But the tamping iron destroyed much of his brain’s left frontal lobe, and Gage’s once even-tempered personality changed dramatically.

Detailed explanation-2: -Phineas Gage is often referred to as the “man who began neuroscience."1 He experienced a traumatic brain injury when an iron rod was driven through his skull, destroying much of his frontal lobe. Gage miraculously survived the accident.

Detailed explanation-3: -Frontal lobe syndrome is a broad term used to describe the damage of higher functioning processes of the brain such as motivation, planning, social behavior, and language/speech production.