GENERAL HISTOLOGY

Detailed explanation-1: -Prader-Willi syndrome (PWS) is a complex neurodevelopmental disorder, characterized by endocrine problems and hyperphagia, indicating hypothalamic-pituitary dysfunction.

Detailed explanation-2: -Prader-Willi syndrome is caused by some missing genetic material in a group of genes on chromosome number 15. This leads to a number of problems and is thought to affect part of the brain called the hypothalamus, which produces hormones and regulates growth and appetite.

Detailed explanation-3: -People with Prader-Willi syndrome develop an increased appetite and eat an excessive amount of food if they have the opportunity. The medical name for this is hyperphagia.

Detailed explanation-4: -The number of oxytocin neurones–the putative satiety neurones–in the hypothalamic paraventricular nucleus is markedly decreased in Prader-Willi syndrome. This is presumed to be the basis of the insatiable hunger and obesity of patients with the syndrome.