GENERAL HISTOLOGY

NERVOUS SYSTEM SPECIAL SENSE

SPINALCORD

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
If voltage-gated sodium channels were blocked, what effect would it have on the function of neurons?
A
the dendrites could not receive signals
B
the dendrites could not have temporal summation
C
the axon would repeatedly generate an action potential
D
the axon could not generate an action potential
Explanation: 

Detailed explanation-1: -Blocking the process of sodium inactivation would affect primarily the repolarization phase of the action potential. There would be no change in the resting potential. The only consequence would be that the action potential would have a greater duration than normal.

Detailed explanation-2: -Block of voltage-gated potassium (Kv) channels has been demonstrated to affect neuronal activity described as increasing excitability. The effect has been associated with a closed-state dependent block. However, the block of Kv channels in e.g. local anesthetic and antiarrhythmics, is open state-dependent.

Detailed explanation-3: -What effect would a chemical that blocks the voltage-gated sodium channels in neuron plasma membranes have on a neuron’s ability to depolarize? if the voltage-gated sodium channels in a neuron’s plasma membrane could not open, sodium ions could not flood into the cell, and it would not be able to depolarize.

There is 1 question to complete.