GENERAL HISTOLOGY

Detailed explanation-1: -In secondary neurulation, the neural tube arises from a solid cord of cells that sinks into the embryo and subsequently hollows out (cavitates) to form a hollow tube.

Detailed explanation-2: -It starts during the 3rd and 4th week of gestation. This process is called primary neurulation, and it begins with an open neural plate, then ends with the neural plate bending in specific, distinct steps. [1] These steps ultimately lead to the neural plate closing to form the neural tube.

Detailed explanation-3: -The neural tube is the primordium of the brain and spinal cord, and the process of its formation is called neurulation. From: Clinical Anatomy of the Spine, Spinal Cord, and Ans (Third Edition), 2014.

Detailed explanation-4: -In primary neurulation, the neural plate creases inward until the edges come in contact and fuse. In secondary neurulation, the tube forms by hollowing out of the interior of a solid precursor.