GENERAL HISTOLOGY

NERVOUS SYSTEM SPECIAL SENSE

SPINALCORD

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
The site in the neuron where EPSPs and IPSPs are integrated (summated) is the ____
A
dendrite
B
axon hillock
C
soma
D
teledendria
Explanation: 

Detailed explanation-1: -A single neuron can receive both excitatory and inhibitory inputs from multiple neurons, resulting in local membrane depolarization (EPSP input) and hyperpolarization (IPSP input). All these inputs are added together at the axon hillock.

Detailed explanation-2: -In short, the summation of EPSPs and IPSPs by a postsynaptic neuron permits a neuron to integrate the electrical information provided by all the inhibitory and excitatory synapses acting on it at any moment.

Detailed explanation-3: -Both IPSPs and EPSPs decay with distance and time. If the axon hillock reaches threshold, it fires an action potential back over the soma and down the axon. Multiple simultaneous EPSPs and IPSPs can add by spatial summation. Repetitive EPSPs and IPSPs add by temporal summation.

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