GENERAL HISTOLOGY

Detailed explanation-1: -Microglia are cells of mesodermal/mesenchymal origin that migrate into the CNS to become resident macrophages within the unique brain microenvironment. Microglia are highly dynamic cells that interact with neurons and nonneuronal cells.

Detailed explanation-2: -Unlike other glial cells, microglia are mesodermal in origin. They are believed to be derived from blood-derived monocytes that move into the brain during embryonic development (Kim & de Vellis 2005).

Detailed explanation-3: -In contrast to other populations of the myeloid lineage, adult microglia derive from primitive myeloid precursors that arise in the yolk sac early during embryonic development, after which they self-maintain locally and independently of blood-borne myeloid precursors.