GENERAL HISTOLOGY

Detailed explanation-1: -In the stomach several mucosal defence mechanisms protect the stomach against hydrochloric acid and noxious agents. The pre-epithelial protection is made up by the mucus-bicarbonate barrier. Mucus and bicarbonate, secreted by mucus cells, create a pH gradient maintaining the epithelial cell surface at near neutral pH.

Detailed explanation-2: -What Is the Gastric Mucosa? The gastric mucosa is a layer of mucous membrane found in the stomach. This lining is found on the inner surface of the stomach, along with the glands and gastric pits. It is always covered in a layer of thick mucus secreted by columnar epithelial and glandular cells.

Detailed explanation-3: -A major function of the intestinal mucus layer is to form a barrier between the intestinal epithelium and the luminal content to protect the intestine from pathogenic invasion.

Detailed explanation-4: -Gastric Surface Mucous Cells The protective epithelial cells which line the surface of the stomach (including gastric pits) are called surface mucous cells. These cells are critical for resisting attack by digestive acid and enzymes. Any disruption of these cells’ function can lead to an ulcer.