GENERAL HISTOLOGY

Detailed explanation-1: -Gastric chief cells secrete pepsin as an inactive zymogen called pepsinogen. Parietal cells within the stomach lining secrete hydrochloric acid that lowers the pH of the stomach. A low pH (1.5 to 2) activates pepsin.

Detailed explanation-2: -Pepsinogens are synthesized and secreted primarily by the gastric chief cells of the human stomach before being converted into the proteolytic enzyme pepsin, which is crucial for digestive processes in the stomach.

Detailed explanation-3: -Pepsinogen is an inactive enzyme secreted by the peptic or chief cells of the stomach. This inative enzyme or the proenzyme is converted into its active form, pepsin, upon exposure to hydrochloric acid (HCl) secreted by the parietal or oxyntic cells of the stomach.

Detailed explanation-4: -Pepsinogen is secreted from peptic (or chief) cells in the oxyntic gland. Some pepsinogen is also secreted from mucosal cells in the gastric antrum and the duodenum. In the presence of gastric acid this proenzyme is converted into active pepsin, which itself catalyzes further conversion from pepsinogen.

Detailed explanation-5: -Of these five components, pepsin is the principal enzyme involved in protein digestion. It breaks down proteins into smaller peptides and amino acids that can be easily absorbed in the small intestine.