GENERAL HISTOLOGY

Detailed explanation-1: -The gastric chief cell is a cell in the stomach that releases pepsinogen and chymosin. Chief cells are also known as a zymogenic cell or peptic cells. Pepsinogen is activated into the digestive enzyme pepsin when it comes in contact with acid produced by gastric parietal cells.

Detailed explanation-2: -Zymogen or chief cells are present in the fundic part of stomach. Chief cells are usually basal in location and secrete gastric digestive enzymes as proenzymes or zymogens; pepsinogen and prorennin.

Detailed explanation-3: -A chief cell/peptic cell/gastric cell/zymogenic cell is a gastric gland cell that releases pepsinogen and gastric lipase. These cells release the chymosin in ruminants. They are present in the cardiac region of the stomach.

Detailed explanation-4: -Gastric chief cells secrete pepsin as an inactive zymogen called pepsinogen.

Detailed explanation-5: -Pepsinogens are synthesized and secreted primarily by the gastric chief cells of the human stomach before being converted into the proteolytic enzyme pepsin, which is crucial for digestive processes in the stomach. Furthermore, pepsin can activate additional pepsinogen autocatalytically.