GENERAL HISTOLOGY

Detailed explanation-1: -The intrinsic factor (IF) is a glycoprotein produced by the parietal cells (oxyntic cells) located at the gastric body and fundus. Intrinsic factor plays a crucial role in the transportation and absorption of the vital micronutrient vitamin B12 (cobalamin, Cbl) by the terminal ileum.

Detailed explanation-2: -Parietal cells produce intrinsic factor, which is required for the absorption of vitamin B12. Therefore, autoimmune destruction of parietal cells reduces B12 levels, causing pernicious anemia.

Detailed explanation-3: -[1][2] Parietal cells play a pivotal role in gastric homeostasis, as well as in the absorption of vitamin B12 (cobalamin) due to the release of intrinsic factor (IF).

Detailed explanation-4: -Intrinsic factor is a glycoprotein produced by parietal cells in the stomach and necessary for the absorption of vitamin B12 in the terminal ileum.

Detailed explanation-5: -Intrinsic factor is a protein that helps your intestines absorb vitamin B12. It is made by cells in the stomach lining.