GENERAL HISTOLOGY

Detailed explanation-1: -When people with celiac disease eat foods with gluten, their immune system reacts by damaging the villi. Because of the damage, the villi are unable to properly absorb iron, vitamins, and other nutrients. This may cause a number of symptoms and other health problems.

Detailed explanation-2: -When the body’s immune system overreacts to gluten in food, the reaction damages the tiny, hairlike projections (villi) that line the small intestine. Villi absorb vitamins, minerals and other nutrients from the food you eat. If your villi are damaged, you can’t get enough nutrients, no matter how much you eat.

Detailed explanation-3: -T cells found in the bowel are normally protective “tissue-healing” cells. However, in those with celiac disease, T cells produce inflammation when exposed to gluten. This inflammation causes damage to the lining of the bowel and produces the acute symptoms that patients experience when they ingest gluten.

Detailed explanation-4: -When people with celiac disease eat gluten (a protein found in wheat, rye, and barley), their body mounts an immune response that attacks the small intestine. These attacks lead to damage on the villi, small fingerlike projections that line the small intestine, that promote nutrient absorption.