GENERAL HISTOLOGY

Detailed explanation-1: -Bile (from Latin bilis), or gall, is a yellow-green fluid produced by the liver of most vertebrates that aids the digestion of lipids in the small intestine. In humans, bile is primarily composed of water, produced continuously by the liver, and stored and concentrated in the gallbladder.

Detailed explanation-2: -About 50% of the bile produced by the liver is first stored in the gallbladder. This is a pear-shaped organ located directly below the liver. Then, when food is eaten, the gallbladder contracts and releases stored bile into the duodenum to help break down the fats.

Detailed explanation-3: -Bilirubin is the main pigment in bile. Bilirubin is a waste product that is formed from hemoglobin (the protein that carries oxygen in the blood) and is excreted in bile. Hemoglobin is released when old or damaged red blood cells are destroyed.

Detailed explanation-4: -Bile is a physiological aqueous solution produced and secreted by the liver. It consists mainly of bile salts, phospholipids, cholesterol, conjugated bilirubin, electrolytes, and water [1]. Bile travels through the liver in a series of ducts, eventually exiting through the common hepatic duct.

Detailed explanation-5: -The generally accepted hypothesis has been that the pigments responsible for the characteristic discoloration in jaundice are manufactured in the liver, whatever the cause of their absorption into the blood may be, and there is agreement in regarding the blood pigment, hemoglobin, as the precursor of the bile pigments.