GENERAL HISTOLOGY

Detailed explanation-1: -Keratohyalin granules primarily exist within the stratum granulosum, with some present in the stratum spinosum. These granules are insoluble in water and located within the cytoplasm where they promote dehydration of the cell.

Detailed explanation-2: -The stratum granulosum comprises keratinocytes that have matured to the point where they are beginning to produce the large amounts of keratin that will eventually fill the cells.

Detailed explanation-3: -Stratum granulosum and stratum lucidum The granule cell layer (stratum granulosum) is the next layer (3-5 layers of cells). As the cells move up into this layer, they start to lose their nuclei and cytoplasmic organelles, and turn into the keratinised squames of the next layer.

Detailed explanation-4: -Stratum Granulosum The cells (three to five layers deep) become flatter, their cell membranes thicken, and they generate large amounts of the proteins keratin, which is fibrous, and keratohyalin, which accumulates as lamellar granules within the cells (see Figure 5.1. 4).