GENERAL HISTOLOGY

Detailed explanation-1: -Desmosomes represent major intercellular adhesive junctions at basolateral membranes of epithelial cells and in other tissues. They mediate direct cell-cell contacts and provide anchorage sites for intermediate filaments important for the maintenance of tissue architecture.

Detailed explanation-2: -Cells adhere to each other and to the extracellular matrix through cell-surface proteins called cell adhesion molecules (CAMs)-a category that includes the transmembrane adhesion proteins we have already discussed.

Detailed explanation-3: -Desmosomes Connect Intermediate Filaments from Cell to Cell Desmosomes are buttonlike points of intercellular contact that rivet cells together (Figure 19-11A).