MRCP UK EXAMINATIONS

ABDOMINAL

CHRONIC LIVER DISEASE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
What is the clinical significance of increased levels of ammonia?
A
indicates kidney failure
B
indicates pancreatic failure
C
indicates liver failure
D
indicates pituitary gland failure
Explanation: 

Detailed explanation-1: -Hepatic encephalopathy, a condition that happens when the liver is too diseased or damaged to properly process ammonia. In this disorder, ammonia builds up in the blood and travels to the brain. It can cause confusion, disorientation, and coma. It can sometimes be fatal.

Detailed explanation-2: -Liver disease is the most common cause of high ammonia levels in adults and children. Hepatic encephalopathy: This is a condition that happens when your liver is too diseased or damaged to properly process ammonia, leading to a buildup of ammonia in your blood that travels to your brain.

Detailed explanation-3: -In the total ACLF population, an ammonia level of ≥ 89 µmol/L is closely correlated with liver, coagulation, and brain failure, although our data did not find a relationship between higher ammonia and kidney, circulation or respiration failure.

Detailed explanation-4: -Hyperammonemia is a metabolic condition characterized by the raised levels of ammonia, a nitrogen-containing compound. Normal levels of ammonia in the body vary according to age. Hyperammonemia can result from various congenital and acquired conditions in which it may be the principal toxin.

There is 1 question to complete.