ABDOMINAL
CHRONIC LIVER DISEASE
|
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
|
|
|
dehydration
|
|
|
reduction
|
|
|
condensation
|
|
|
hydrolysis
|
Detailed explanation-1: -This reaction is ATP dependent and is catalyzed by argininosuccinate synthetase. Argininosuccinate undergoes cleavage by argininosuccinase to form arginine and fumarate. Arginine is cleaved by arginase to form urea and ornithine.
Detailed explanation-2: -The urea cycle or ornithine cycle converts excess ammonia into urea in the mitochondria of liver cells. The urea forms, then enters the blood stream, is filtered by the kidneys and is ultimately excreted in the urine.
Detailed explanation-3: -The final reaction of the cycle is the hydrolysis of arginine to urea and ornithine by arginase. The major regulatory step is catalyzed by CPS-I where the positive effector is N-acetyl glutamate (NAG). It is formed from glutamate and acetyl CoA . Arginine is an activator of NAG synthase.