MRCP UK EXAMINATIONS

Detailed explanation-1: -Gastrin is a peptide hormone primarily responsible for enhancing gastric mucosal growth, gastric motility, and secretion of hydrochloric acid (HCl) into the stomach. It is present in G cells of the gastric antrum and duodenum.

Detailed explanation-2: -The antrum of the stomach contains pyloric glands, and their main feature is the presence of gastrin-secreting G cells. Somatostatin-secreting D cells are present in the pyloric and oxyntic glands and modulate gastrin release and gastric acid secretion [1].

Detailed explanation-3: -Gastrin, secretin, and cholecystokinin (CCK) were the first discovered gut hormones, and as of today, there are more than 50 gut hormone genes and a multitude of bioactive peptides, which makes the gut as the largest endocrine organ of the body.