ABDOMINAL
GASTROINTESTINAL
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Factors that help intestinal motility
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Factors that inhibit intestinal motility
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Either A or B
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None of the above
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Detailed explanation-1: -Glucagon retards gastric emptying of liquids and inhibits motility throughout the gastrointestinal tract [63].
Detailed explanation-2: -Through nicotinic synapses, secretin stimulates VIP release from postganglionic neurons in the gastric myenteric plexus, which in turn induces gastric relaxation through a prostaglandin-dependent pathway. Secretin has been shown to inhibit gastric contractions and delay gastric emptying of liquids and solids.
Detailed explanation-3: -In mammals, ghrelin (GHRL) and motilin (MLN) stimulate appetite and GI motility and contribute to the regulation of energy homeostasis. GHRL and MLN are produced in the mucosal layer of the stomach and upper small intestine, respectively.
Detailed explanation-4: -Under normal physiologic conditions, secretin inhibits gastrin release; however, in gastrinoma pathologies, the administration of secretin will cause an overall increase in gastrin release.