MRCP UK EXAMINATIONS

Detailed explanation-1: -Brunner’s glands are located in the submucosa of the duodenum. They secrete an alkaline fluid containing mucin, which protects the mucosa from the acidic stomach contents entering the duodenum.

Detailed explanation-2: -Brunner’s gland adenoma, also known as Brunneroma or polypoid hamartoma, is a rare, benign, proliferative lesion arising from the Brunner’s glands of the duodenum, accounting for 10.6% of benign tumors of the duodenum. The time patients are usually asymptomatic and lesions are discovered incidentally.

Detailed explanation-3: -Brunner’s glands (or duodenal glands) are compound tubular submucosal glands found in that portion of the duodenum which is above the hepatopancreatic sphincter (i.e sphincter of Oddi). It also contains submucosa which creates special glands.

Detailed explanation-4: -The Brunner glands of the duodenal mucosa produce an alkaline solution and enterogastrone (an inhibitor of gastric acid secretion). These two actions are thought to play an important role in limiting peptic ulcer formation between the pylorus and ampulla of Vater.

Detailed explanation-5: -Human Brunner’s glands produce class III mucin glycoproteins and are thought to be the product of mucin gene MUC6 which is assigned to chromosome 11 (11p15-11p15. 5 chromosome region).