MRCP UK EXAMINATIONS

ABDOMINAL

GASTROINTESTINAL

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Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]

which one is conserved amino acid in gastrin and CCK?

A	Pentagastrin
B	Octagastrin
C	Heptagastrin
D	trigastrin

Explanation:

Detailed explanation-1: -Gastrin is the major stimulant of gastric acid secretion and has a growth stimulatory effect on the secretory part of the stomach. The physiological roles of CCK are the stimulation of pancreatic secretion and the contraction of the gall-bladder.

Detailed explanation-2: -Cholecystokinin (CCK) and gastrin together constitute a family of homologous peptide hormones, which are both physiological ligands for the gastrin/CCK-B receptor, whereas the CCK-A receptor binds only sulfated CCK-peptides. CCK peptides are mainly produced in small intestinal endocrine I-cells and in cerebral neurons.

Detailed explanation-3: -Phenylalanine and tryptophan were significantly more potent stimulants of gastric acid secretion and of pancreatic polypeptide and gastrin release than any of the other amino acids tested.

There is 1 question to complete.