ABDOMINAL
GENERALISED LYMPHADENOPATHY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Hashimoto’s goiter
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Colloid goiter
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Endemic goiter
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Diffuse toxic goiter
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Detailed explanation-1: -Hashimoto thyroiditis is a histologic diagnosis. Typically, the thyroid gland shows diffuse lymphocytic and plasma cell infiltration with formation of lymphoid follicles from follicular hyperplasia and damage to the follicular basement membrane. Atrophy of the thyroid parenchyma is usually evident.
Detailed explanation-2: -Background: Intrathyroid lymphoid tissue is accrued in Hashimoto thyroiditis (HT). Histologically, this acquired lymphoid tissue bears a close resemblance to mucosa-associated lymphoid tissue (MALT) and can evolve to lymphoma.
Detailed explanation-3: -Histologically, the thyroid gland is organized as epithelial cells surrounding colloid-containing pools, called follicles. The colloid is rich in thyroglobulin, a protein possessing many tyrosine residues to which iodine molecules attach to form the thyroid hormones.
Detailed explanation-4: -Hashimoto’s thyroiditis (HT) is the most common autoimmune disease characterized by lymphocytic infiltration and thyrocyte destruction. Dissection of the interaction between the thyroidal stromal microenvironment and the infiltrating immune cells might lead to a better understanding of HT pathogenesis.