MRCP UK EXAMINATIONS

ABDOMINAL

THALASSEMIA

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
A 25-year-old man is getting married in the next 2 months. come to consult about thalassemia anemia Blood concentration test results are as follows:Hb 13 g/dl, Hct 41%, MCV 82 fl, RDW 15%OF-ve, DCIP-ve What advice would you give?
A
normal blood results without thalassemia There is no need to bring the wife to come for the examination.
B
Further testing should be performed as it may be a carrier of alpha thalassemia.
C
Further testing should be performed as it may be a beta thalassemia carrier.
D
should be examined further because it may be a carrier of both alpha and beta thalassemia
Explanation: 

Detailed explanation-1: -Thalassemia intermedia is characterized by Hb level between 7 and 10 g/dl, MCV between 50 and 80 fl and MCH between 16 and 24 pg. Thalassemia minor is characterized by reduced MCV and MCH, with increased Hb A2 level [29].

Detailed explanation-2: -The MCV is usually less than 75 fl with thalassemia and rarely less than 80 fl in iron deficiency until the hematocrit is less than 30 percent. For children, the Mentzer index (MCV/red blood cell count) can help distinguish between iron deficiency and thalassemia.

Detailed explanation-3: -The gold standard for the diagnosis of -thalassemia carriers is electrophoresis or HPLC analysis of hemoglobin (Hgb). Automated blood count results that suggest -thalassemia carrier status can significantly improve the recognition of carriers and consequently of couples at risk.

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