ABDOMINAL
THALASSEMIA
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Hemoglobin E migrates with which of the following on alkaline electrophoresis?
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HbF
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HbS & C
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HbA2 & C
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HbA & F
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Explanation:
Detailed explanation-1: -In alkaline electrophoresis, hemoglobin molecules assume a negative charge and migrate toward the anode (positive pole). Historically, alkaline hemoglobin electrophoresis was performed on cellulose acetate medium, but it is being replaced by agarose medium.
Detailed explanation-2: -Of the hemoglobins normally present in an adult, Hb A migrates the fastest, followed by Hb F.
Detailed explanation-3: -HbA2, composing of two chains and two chains, is a minor component of the hemoglobin present in normal adult red blood cells, accounting for about 2.5% of the total hemoglobin in healthy individuals. However, HbA2 level is also elevated in some pregnant women.
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