MRCP UK EXAMINATIONS

Detailed explanation-1: -Beta-globin is a component (subunit) of a larger protein called hemoglobin, which is located inside red blood cells. In adults, hemoglobin consists of four protein subunits: usually two subunits of beta-globin and two subunits of a protein called alpha-globin, which is produced from another gene called HBA.

Detailed explanation-2: -Adult hemoglobin is composed of two alpha () and two beta () polypeptide chains. There are two copies of the hemoglobin alpha gene (HBA1 and HBA2), which each encode an -chain, and both genes are located on chromosome 16. The hemoglobin beta gene (HBB) encodes the -chain and is located on chromosome 11.

Detailed explanation-3: -Alpha-globin is a component (subunit) of a larger protein called hemoglobin, which is the protein in red blood cells that carries oxygen to cells and tissues throughout the body. Hemoglobin is made up of four subunits: two subunits of alpha-globin and two subunits of another type of globin.

Detailed explanation-4: -HBB Gene-Hemoglobin Subunit Beta The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia.