ABDOMINAL
THALASSEMIA
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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T/F:Sickle cell disease is negative for Dithionate solubility test.
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False
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True
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Either A or B
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None of the above
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Explanation:
Detailed explanation-1: -The Hemoglobin Solubility Test detects Hb S, which is present in individuals with sickle cell anemia or sickle cell trait. “Solubility” refers to how well a substance dissolves in a liquid. In this case, the substance is the hemoglobin molecule, the major protein in RBCs, and the liquid is blood plasma.
Detailed explanation-2: -1. False positives may occur in patients with erythrocytosis, hyperglobulinaemia, extreme leukocytosis or hyperlipidaemia. Coarse flocculation may occur in these samples due to elevated levels of total serum protein.
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