MRCP UK EXAMINATIONS

Detailed explanation-1: -Sickle cell disease is an inherited blood disorder marked by defective hemoglobin. It inhibits the ability of hemoglobin in red blood cells to carry oxygen. Sickle cells tend to stick together, blocking small blood vessels causing painful and damaging complications.

Detailed explanation-2: -People who have this form of SCD inherit two genes, one from each parent, that code for hemoglobin “S.” Hemoglobin S is an abnormal form of hemoglobin that causes the red cells to become rigid, and sickle shaped. This is commonly called sickle cell anemia and is usually the most severe form of the disease.

Detailed explanation-3: -Vaso-occlusive crisis in patients with SCD is a multifactorial process characterized by inflammation, adhesion, and multicellular aggregation of sickled RBCs, endothelial cells, platelets, and other blood cells, resulting in vaso-occlusion and acute severe pain.