MRCP UK EXAMINATIONS

Detailed explanation-1: -Persons with beta thalassemia major live an average of 17 years and usually die by 30 years of age. Most deaths are caused by the cardiac complications of iron overload.

Detailed explanation-2: -patients with thalassemia that they can expect a normal lifespan – provided that they receive regular transfusions and remain adherent with their chelation therapy.

Detailed explanation-3: -Clinical presentation of thalassemia major occurs between 6 and 24 months. Affected infants fail to thrive and become progressively pale. Feeding problems, diarrhea, irritability, recurrent bouts of fever, and progressive enlargement of the abdomen caused by spleen and liver enlargement may occur.

Detailed explanation-4: -Pain is a major cause of morbidity and an unrecognized problem for patients with thalassaemia. Age is the strongest predictor of frequency and severity.