ABDOMINAL
THALASSEMIA
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Which of these is not a pathophysiology of SCD?
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Reversible vs. irreversible sickled cells
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extravascular hemolysis of sickled cells
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Increased solubility of Hgb S in oxygenated state, molecules depolymerize into flexible aggregates
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microvasculature blockages lead to tissue necrosis
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Explanation:
Detailed explanation-1: -Vaso-occlusive crisis in patients with SCD is a multifactorial process characterized by inflammation, adhesion, and multicellular aggregation of sickled RBCs, endothelial cells, platelets, and other blood cells, resulting in vaso-occlusion and acute severe pain.
Detailed explanation-2: -Pathogenesis. Hemoglobin S results from the inherited substitution of valine for glutamic acid as the sixth amino acid of the beta globin chain. This change produces profound alterations in the stability and solubility of the hemoglobin molecule.
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