MRCP UK EXAMINATIONS

ABDOMINAL

THALASSEMIA

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Thalassemia major (severe thalassemia) Homozygous
A
True
B
False
C
Either A or B
D
None of the above
Explanation: 

Detailed explanation-1: -In beta thalassemia major (ie, homozygous beta thalassemia), the production of the beta-globin chains is severely impaired because both beta-globin genes are mutated. The severe imbalance of globin chain synthesis (alpha » beta) results in ineffective erythropoiesis and severe microcytic hypochromic anemia.

Detailed explanation-2: -Beta thalassemia major (Cooley’s anemia). Beta thalassemia minor or thalassemia trait. Beta thalassemia major: This is the most severe type of this disorder. Thalassemia minima: This type often causes no symptoms. More items

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