ABDOMINAL
THALASSEMIA
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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When one a gene is deleted (a-/aa), a patient has:
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Normal hemoglobin levels
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Mild anemia (hemoglobin range 9 to 11 g/dL)
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Moderate anemia (hemoglobin range 7 to 9 gm/dL)
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Marked anemia requiring regular transfusions
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Explanation:
Detailed explanation-1: -What is alpha thalassemia? Alpha thalassemia is a condition which affects the hemoglobin in the blood. Hemoglobin is the part of the red blood cells that carries oxygen through the body. Alpha thalassemia is found most often in people of Asian origin, but it also regularly appears in people of African ancestry.
Detailed explanation-2: -HbH disease is usually caused by loss or alteration of three of the four alpha-globin alleles, which sharply reduces the amount of normal alpha-globin produced. Because nondeletion variants are usually more severe than deletions, nondeletion variants in two of the four alpha-globin alleles can result in HbH disease.
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