ABDOMINAL
THALASSEMIA
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Which of these is NOT a Quantitative disorder of Thalassemias?
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Named according to decreased chainAlpha ThalassemiaBeta Thalassemia
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Causes an imbalance between “partner” chains
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Result of various genetic defects that cause decreased synthesis of normal globin chains
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Altered amino acid sequence causes globin chains to behave differently-structurally, electrochemically, and functionally
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Explanation:
Detailed explanation-1: -Thalassemia is a quantitative problem of too few globins synthesized, whereas sickle-cell disease (a hemoglobinopathy) is a qualitative problem of synthesis of an incorrectly functioning globin.
Detailed explanation-2: -Thalassemia differs from sickle cell anaemia in that the former is qualitative problem of synthesising an incorrectly functioning globin while the latter is a quantitative problem of synthesising too few globin molecules.
Detailed explanation-3: -Thalassemias: Thalassemias are quantitative defects that lead to reduced levels of one type of globin chain, creating an imbalance in the ratio of alpha-like chains to beta-like chains.
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