MRCP UK EXAMINATIONS

Detailed explanation-1: -Janeway lesions are irregular, nontender hemorrhagic macules located on the palms, soles, thenar and hypothenar eminences of the hands, and plantar surfaces of the toes. They typically last for days to weeks. They are usually seen with the acute form of bacterial endocarditis.

Detailed explanation-2: -Janeway lesions are painless, erythematous hemorrhagic macules, papules, or nodules that appear on the palms and soles, while Osler’s nodes are painful, purple or red nodules that typically manifest on the fingertips and toes.

Detailed explanation-3: -They are caused by septic emboli that deposit bacteria leading to formation of microabscesses. Janeway lesions are less commonly seen now, as most infective endocarditis are diagnosed and treated early.

Detailed explanation-4: -Janeway lesions are rare, non-tender, small erythematous or haemorrhagic macular, papular or nodular lesions on the palms or soles only a few millimeters in diameter that are associated with infective endocarditis and often indistinguishable from Osler’s nodes.