MRCP UK EXAMINATIONS

CARDIOLOGY

MIXED AORTIC VALVE DISEASE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
In degenerative valvular heart diseases (VHD), the extra cellular matrix (ECM) of the valve is affected. Among the mentioned answers, which does not affect the integrity of degenerative VHD?
A
Calcification
B
Alteration in ECM
C
Changes in production of matrix metalloproteinases or their inhibitors
D
Bacterial infection
Explanation: 

Detailed explanation-1: -Any valve in the heart can become diseased, but the aortic valve is most commonly affected. Diseased valves can become “leaky” where they don’t completely close; this is called regurgitation.

Detailed explanation-2: -Acquired valve diseases more commonly affect the aortic or mitral valves. The aortic valve sits between the lower left chamber of your heart, called the left ventricle, and major blood vessel called the aorta.

Detailed explanation-3: -Infective endocarditis, also called bacterial endocarditis, is an infection caused by bacteria that enter the bloodstream and settle in the heart lining, a heart valve or a blood vessel. IE is uncommon, but people with some heart conditions have a greater risk of developing it.

Detailed explanation-4: -Abstract. Pulmonary hypertension (PH) is a classic pathophysiological consequence of left-sided valvular heart disease (VHD).

There is 1 question to complete.