MRCP UK EXAMINATIONS

Detailed explanation-1: -If your child receives tube feedings with such a product, give the phenytoin at least 1 hour before or 2 hours after feeding. If your child receives continuous tube feedings, stop the tube feedings for 1 hour before giving the medicine.

Detailed explanation-2: -Ideally, the feeds should be held for 1–2 hours before and after each phenytoin dose with adequate tube flushes before and after phenytoin administration.

Detailed explanation-3: -Dolutegravir should be separated from enteral feeding for two hours before and after drug administration. Levodopa should be avoided with large protein doses, and therefore should be separated from intermittent feeds or protein administration by two hours.

Detailed explanation-4: -Nonionized phenytoin is irreversibly bound to NG tubing from solution at the pH of enteral nutrient solutions while this is not the case for anionic phenytoin in unbuffered water or saline.

Detailed explanation-5: -(Seizures) Phenytoin reacts with the enteral feeding tube itself and the protein in the feed. This reduces drug absorption and consequent plasma concentration 2 hour break in feeding pre and post drug administration (oral or enteral dose). Not applicable if prescribed intravenously (IV).