CLINICAL ENCOUNTERS
ANTICOAGULATION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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known allergy
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ATCD of heparin-induced thrombocytopenia HIT
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Disorders of haemostasis, situation at risk of haemorrhage
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Severe kidney failure
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Elderly subjects
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Detailed explanation-1: -NICE and the BNF suggest that contraindications to all heparins include trauma, epidural half-life, hemorrhagic disorders, peptic ulcer disease, recent cerebral hemorrhage, severe hypertension, and recent surgery to the eye or nervous system.
Detailed explanation-2: -Enoxaparin is contraindicated in patients with active major bleeding, in patients with thrombocytopenia associated with a positive in vitro test for anti-platelet antibody in the presence of enoxaparin sodium, or in patients with hypersensitivity to enoxaparin.
Detailed explanation-3: -When bleeding risk exceeds the risk of stroke, treatment should be discontinued; however, this is associated with an increased risk of death and thromboembolic complications [5].
Detailed explanation-4: -Known hypersensitivity to enoxaparin (urticaria, anaphylactoid reactions, anaphylaxis) or any heparin products[27][28] Active major bleeding such as gastrointestinal bleed. History of heparin-induced thrombocytopenia within the past 100 days or presence of circulating antibodies[29] More items •10-Sept-2022