MRCP UK EXAMINATIONS

Detailed explanation-1: -Fibrinolysis is a highly regulated enzymatic process that prevents unnecessary accumulation of intravascular fibrin and enables the removal of thrombi. Fibrin surfaces are key activation sites for fibrinolysis that modulate the binding of plasminogen and plasmin [29].

Detailed explanation-2: -Fibrinolysis is the enzymatic breakdown of fibrin in blood clots. Plasmin cuts the fibrin mesh at various places, leading to the production of circulating fragments that are cleared by other proteases. Primary fibrinolysis is a normal body process.

Detailed explanation-3: -Fibrinogen is a soluble macromolecule, but forms an insoluble clot or gel on conversion to fibrin by the action of the serine protease thrombin, which is activated by a cascade of enzymatic reactions triggered by vessel wall injury, activated blood cells, or a foreign surface (Fig. 13.1).

Detailed explanation-4: -Proteolytic enzymes in general, but more particularly trypsin and chymotrypsin, are known for their ability to digest fibrin clots; certain snake venoms can also do this. The proteolysis of fibrinogen and fibrin by venoms, trypsin or plasmin appears to vary, depending upon which of the enzyme is used.