MRCP UK EXAMINATIONS

Detailed explanation-1: -Prothrombin, FVII, FIX, protein C, and protein S are vitamin K-dependent clotting factors or proteins strictly related to blood coagulation.

Detailed explanation-2: -Factor X is a vitamin K dependent, liver produced serine protease that serves as a pivotal role in coagulation as the first enzyme in the common pathways to thrombus formation. It is located on chromosome 13 (13q34) and its deficiency can be inherited or acquired.

Detailed explanation-3: -The vitamin K-dependent coagulation factors are factors II, VII, IX, X, proteins C and S. Combined deficiency of the vitamin K-dependent factors may result from missense mutations in the genes for vitamin K reductase (VKORC-1) or gamma-glutamyl carboxylase.