MRCP UK EXAMINATIONS

Detailed explanation-1: -The intricate pathway allows for rapid healing and prevention of spontaneous bleeding. Two paths, intrinsic and extrinsic, originate separately but converge at a specific point, leading to fibrin activation. The purpose is to ultimately stabilize the platelet plug with a fibrin mesh.

Detailed explanation-2: -The intrinsic pathway is activated through exposed endothelial collagen, and the extrinsic pathway is activated through tissue factor released by endothelial cells after external damage.

Detailed explanation-3: -Blood clotting, or coagulation, is an important process that prevents excessive bleeding when a blood vessel is injured. Platelets (a type of blood cell) and proteins in your plasma (the liquid part of blood) work together to stop the bleeding by forming a clot over the injury.

Detailed explanation-4: -The pathway of blood coagulation activated by tissue factor, a protein extrinsic to blood, is known as the extrinsic pathway (Figure 1).

Detailed explanation-5: -1) Constriction of the blood vessel. 2) Formation of a temporary “platelet plug.” 3) Activation of the coagulation cascade. 4) Formation of “fibrin plug” or the final clot.