MRCP UK EXAMINATIONS

Detailed explanation-1: -The common pathway factors X, V, II, I, and XIII are also known as Stuart-Prower factor, proaccelerin, prothrombin, fibrinogen, and fibrin-stabilizing factor, respectively. Clotting factor IV is a calcium ion that plays an important role in all 3 pathways.

Detailed explanation-2: -The common pathway consists of factors I, II, V, VIII, X. The factors circulate through the bloodstream as zymogens and are activated into serine proteases.

Detailed explanation-3: -Factor X is at the confluence of the extrinsic pathway and the intrinsic pathway and can be activated by the TF/fVIIa complex or the fIXa/fVIIIa complex. A deficiency of fX, which is one of the rarest of the hereditary bleeding disorders, exhibits an autosomal recessive inheritance.

Detailed explanation-4: -Coagulation Factor X is a vitamin K-dependent, liver-produced serine protease that serves as the first enzyme in the coagulation cascade to form fibrin. It is a two-chain glycoprotein with the molecular weight of approximately 59 kDa 2.

Detailed explanation-5: -Factor X is a clotting protein (also called a clotting factor). Clotting factors are specialized proteins that are essential for proper clotting, the process by which blood clumps together to plug the site of a wound to stop bleeding. Clotting requires a series of reactions to ultimately form a clot to plug a wound.