CLINICAL ENCOUNTERS
DIABETIC RETINOPATHY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Rearrange the sequence of loss of glycosaminoglycans (GAGs) in diabetic retinopathy?i. Vascular leakage from the retinal capillaries followed by microaneurysmsii. Collagen progressively replaces the GAGs of the basal membraneiii. The substitution of GAGs by collagen leads to a basal membrane thickeningiv. Vascular permeability due to altered anionic charge
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i, ii, iii, iv
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ii, iii, i, iv
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iii, ii, iv, i
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ii, iii, iv, i
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Explanation:
Detailed explanation-1: -(a) Stage I: No diabetic retinopathy; (b) Stage II: Mild non-proliferative diabetic retinopathy; (c) Stage III: Moderate non-proliferative diabetic retinopathy; (d) Stage IV: Severe non-proliferative diabetic retinopathy; (e) Stage V: Proliferative diabetic retinopathy.
Detailed explanation-2: -Vascular Changes in Diabetic Retinopathy In the diabetic retina, nonperfused and obliterated microvessels are observed in the early stages of retinopathy. Vessel closure promotes the proliferative retinal neovascularization and can be histologically observed as the prevalence of acellular capillaries increases.
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