MRCP UK EXAMINATIONS

CLINICAL ENCOUNTERS

OSTEOPOROSIS

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
PTH indirectly stimulates osteoclasts to release calcium from bones into the blood. This results in
A
lower blood calcium levels and higher bone calcium levels
B
lower levels of both blood and bone calcium
C
higher levels of both blood and bone calcium
D
higher blood calcium levels and lower bone calcium
Explanation: 

Detailed explanation-1: -A primary problem in the parathyroid glands, producing too much parathyroid hormone causes raised calcium levels in the blood (hypercalcaemia) and this is referred to as primary hyperparathyroidism.

Detailed explanation-2: -PTH receptor signaling in osteoblasts and osteocytes can increase the RANKL/OPG ratio, increasing both osteoclast recruitment and osteoclast activity, and thereby stimulating bone resorption.

Detailed explanation-3: -This hormone raises calcium levels by releasing calcium from your bones, increasing the amount of calcium absorbed from your small intestine and decreasing the amount of calcium lost in urine. When blood-calcium levels are too high, the parathyroid glands produce less parathyroid hormone.

Detailed explanation-4: -When you have low levels of parathyroid hormone (PTH) in your blood, it causes you to have low levels of calcium in your blood (hypocalcemia) and high levels of phosphorous in your blood (hyperphosphatemia), which cause certain symptoms and health conditions.

There is 1 question to complete.