CLINICAL ENCOUNTERS
RHEUMATOID ARTHRITIS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Non-selective NSAIDs:
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Anti-inflammatory
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Reversible inhibition of COX-2 isozyme
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Reversible inhibition of both COX-1 and COX-2 isozyme
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Reduction in prostaglandin synthesis
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Explanation:
Detailed explanation-1: -Nonsteroidal antiinflammatory drugs (NSAIDs) are the most commonly prescribed analgesics worldwide. These agents reduce pain, inflammation, and fever by inhibiting cyclooxygenase (COX), which results in decreased synthesis of prostaglandins.
Detailed explanation-2: -Nonselective NSAIDs-Nonselective NSAIDs include drugs commonly available without prescription, such as aspirin, ibuprofen (Advil, Motrin), and naproxen (Aleve), as well as many prescription-strength NSAIDs.
Detailed explanation-3: -Aspirin and a large number of nonsteroidal anti-inflammatory drugs act primarily through the inhibition of prostaglandin synthesis by inhibiting the enzyme cyclooxygenase.
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