MRCP UK EXAMINATIONS

NEUROLOGY

PARKINSON S DISEASE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Which of the following best characteristic of parkinson’s disease
A
Deterioration in the myelin sheath
B
Memory loss
C
Deterioration of dopamine-releasing neuron
D
Immune system breakdown
Explanation: 

Detailed explanation-1: -The degeneration of the dopaminergic neurons in the brain is thought to play a key role in the development of Parkinson’s disease.

Detailed explanation-2: -The cardinal motor symptoms of Parkinson’s disease (PD) are caused by the death of dopaminergic neurons in the substantia nigra pars compacta (SNc).

Detailed explanation-3: -In PD the nerve cells that produce dopamine are dying. The PD symptoms of tremor and stiffness occur when the nerve cells fire and there isn’t enough dopamine to transmit messages. High levels of glutamate, another neurotransmitter, also appear in PD as the body tries to compensate for the lack of dopamine.

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